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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RUNX2
All Species:
14.85
Human Site:
Y299
Identified Species:
29.7
UniProt:
Q13950
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13950
NP_001015051.3
521
56648
Y299
Q
S
S
P
P
W
S
Y
D
Q
S
Y
P
S
Y
Chimpanzee
Pan troglodytes
XP_001142127
523
56886
Y301
Q
S
S
P
P
W
S
Y
D
Q
S
Y
P
S
Y
Rhesus Macaque
Macaca mulatta
XP_001100855
590
64548
Y368
Q
S
S
P
P
W
S
Y
D
Q
S
Y
P
S
Y
Dog
Lupus familis
XP_532158
467
50795
S248
P
P
W
S
Y
D
Q
S
Y
P
S
Y
L
S
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q08775
607
66186
Y385
Q
S
S
P
P
W
S
Y
D
Q
S
Y
P
S
Y
Rat
Rattus norvegicus
Q63046
450
48538
F232
S
L
N
H
S
T
A
F
N
P
Q
P
Q
S
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511294
367
39929
I149
N
P
Q
G
Q
S
Q
I
T
D
P
R
Q
T
Q
Chicken
Gallus gallus
NP_989459
472
51671
F250
L
N
S
A
P
S
P
F
N
P
Q
G
Q
S
Q
Frog
Xenopus laevis
Q6PF39
462
50351
D244
Q
G
Q
I
Q
V
A
D
T
R
Q
V
Q
A
S
Zebra Danio
Brachydanio rerio
NP_998023
467
51296
S248
P
Q
G
Q
T
Q
I
S
D
P
R
Q
A
Q
S
Tiger Blowfish
Takifugu rubipres
NP_001027815
463
50317
G245
A
N
S
F
N
P
Q
G
Q
T
Q
I
T
D
P
Fruit Fly
Dros. melanogaster
Q9W349
826
84703
G481
V
T
P
T
G
G
G
G
G
V
A
A
G
G
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
88.3
72.1
N.A.
85
60.2
N.A.
66.9
88.2
59.8
76.5
72.7
23.2
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
88.3
75.8
N.A.
85.6
71
N.A.
67.7
89.6
71.2
82.3
80.2
33.5
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
20
N.A.
100
6.6
N.A.
0
20
6.6
6.6
6.6
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
20
N.A.
100
33.3
N.A.
6.6
40
26.6
6.6
13.3
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
9
0
0
17
0
0
0
9
9
9
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
9
0
9
42
9
0
0
0
9
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
9
0
0
0
17
0
0
0
0
0
0
0
% F
% Gly:
0
9
9
9
9
9
9
17
9
0
0
9
9
9
0
% G
% His:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
9
0
0
9
9
0
0
0
9
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
9
9
0
0
0
0
0
0
0
0
0
0
9
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
17
9
0
9
0
0
0
17
0
0
0
0
0
0
% N
% Pro:
17
17
9
34
42
9
9
0
0
34
9
9
34
0
9
% P
% Gln:
42
9
17
9
17
9
25
0
9
34
34
9
34
9
34
% Q
% Arg:
0
0
0
0
0
0
0
0
0
9
9
9
0
0
0
% R
% Ser:
9
34
50
9
9
17
34
17
0
0
42
0
0
59
17
% S
% Thr:
0
9
0
9
9
9
0
0
17
9
0
0
9
9
0
% T
% Val:
9
0
0
0
0
9
0
0
0
9
0
9
0
0
9
% V
% Trp:
0
0
9
0
0
34
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
0
0
34
9
0
0
42
0
0
34
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _